PRC2, CHROMATIN REGULATION, AND HUMAN DISEASE: INSIGHTS FROM MOLECULAR STRUCTURE AND FUNCTION

Polycomb repressive complex 2 (PRC2) is a multisubunit histone-modifying enzyme complex that mediates methylation of Barrel Style histone H3 lysine 27 (H3K27).Trimethylated H3K27 (H3K27me3) is an epigenetic hallmark of gene silencing.PRC2 plays a crucial role in a plethora of fundamental biological processes, and PRC2 dysregulation has been repeate

Background: Sleep deprivation (SD) has emerged as a significant public health concern because of its adverse effects on cognition and behavior.However, the influence of circadian rhythms on SD and brain Power Reclining Loveseat with Console activities has been less studied.This study employed functional magnetic resonance imaging (fMRI) and functio